Medical Pharmacology & Therapeutics, now in its fifth edition, offers medical students all they need to know to become safe and effective prescribers. It forms a complete, integrated resource for basic pharmaceutical science, pathophysiology, clinical pharmacology, and therapeutics. The fifth edition has been extensively revised and updated throughout. Key features include: Clear, disease-based approach. Presentation of how drugs are used in clinical practice. Succinct explanations of the major pathogenic mechanisms of each disease and consequent clinical signs and symptoms. Comprehensive reviews of major drug classes relevant to each disease. Structured approach to the principles of disease management - outlining core principles of drug choice and planning a therapeutic regimen for common diseases. Quick-reference drug compendia illustrating key similarities and differences among all BNF-listed drugs in each class. Comes with free e-book on StudentConsult. New sections on key and evolving topics, including prescribing safety and pharmacovigilance. Updated figures to further clarify complex areas. Over 800 revised multiple-choice and case-based questions for self-assessment.

This Executive Summary highlights findings from a comparative historical analysis of the four Quadrennial Defense Reviews conducted after 1997 (in 2001, 2006, 2010, and 2014), identifying trends, implications, and recommendations for the Army and Defense Department in order to shape the conduct of and improve future reviews.

Groundbreaking essays and commentaries on the ways that recent findings in psychology and neuroscience illuminate virtue and character and related issues in philosophy.

Astronomer Gerard P. Kuiper ignored the traditional boundaries of his subject. Using telescopes and the laboratory, he made the solar system a familiar, intriguing place. "It is not astronomy," complained his colleagues, and they were right. Kuiper had created a new discipline we now call planetary science. Kuiper was an acclaimed astronomer of binary stars and white dwarfs when he accidentally discovered that Titan, the massive moon of Saturn, had an atmosphere. This turned our understanding of planetary atmospheres on its head, and it set Kuiper on a path of staggering discoveries: Pluto was not a planet, planets around other stars were common, some asteroids were primary while some were just fragments of bigger asteroids, some moons were primary and some were captured asteroids or comets, the atmosphere of Mars was carbon dioxide, and there were two new moons in the sky, one orbiting Uranus and one orbiting Neptune.He produced a monumental photographic atlas of the Moon at a time when men were landing on our nearest neighbor, and he played an important part in that effort. He also created some of the world's major observatories in Hawai`i and Chile. However, most remarkable was that the keys to his success sprang from his wartime activities, which led him to new techniques. This would change everything.Sears shows a brilliant but at times unpopular man who attracted as much dislike as acclaim. This in-depth history includes some of the twentieth century's most intriguing scientists, from Harold Urey to Carl Sagan, who worked with-and sometimes against-the father of modern planetary science. Now, as NASA and other space agencies explore the solar system, they take with them many of the ideas and concepts first described by Gerard P. Kuiper.

First published in 1998, William Bowen and Derek Bok's The Shape of the River became an immediate landmark in the debate over affirmative action in America. It grounded a contentious subject in concrete data at a time when arguments surrounding it were characterized more by emotion than evidence--and it made a forceful case that race-conscious admissions were successfully helping to promote equal opportunity. Today, the issue of affirmative action remains unsettled. Much has changed, but The Shape of the River continues to present the most compelling data available about the effects of affirmative action. Now with a new foreword by Nicholas Lemann and an afterword by Derek Bok, The Shape of the River is an essential text for anyone seeking to understand race-conscious admissions in higher education.

This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-a-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development. Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.

A total CBT training solution, with practical strategies for improving educational outcomes. Teaching and Supervising Cognitive Behavioral Therapy is the first comprehensive package to provide empirically-validated CBT training and supervisory techniques. Applicable to a variety of behavioral health care disciplines, this multi-modal guide provides educators with the information and tools that can help improve educational outcomes. An examination of CBT developments over the past twenty years leads into a discussion of practical applications for improving CBT education, while addressing the technological advances that facilitate dissemination and the specific challenges posed to confidentiality and patient care. The digital component contains additional audio and video content, plus downloadable worksheets that reinforce and expand upon the strategies presented. Coverage includes advice geared specifically toward the most commonly-encountered problems, with video of training sessions that address issues like frustration with patients, disbelief in psychotherapy, dislike of the method, and lack of skills.Readers will gain insight into effective goal setting, and implement a structured approach to supervision. * Examine existing literature and research on training, supervision, and evaluation * Integrate theory with practical strategies to improve learning outcomes * Customize training approaches to specifically suit different professional groups * Fit the methods to the environment, including workshops, webinars, and podcasts Mental health professionals who favor an empirically-based approach to therapy will appreciate the effectiveness of an empirically-based approach to pedagogy. Backed by over two decades of CBT research and the insight of leading CBT experts, Teaching and Supervising Cognitive Behavioral Therapy provides trainers with the tools and information they need to improve therapist educational outcomes.

The long-awaited, definitive book for lovers of the low-end. Willie G. Moseley, Senior Writer for Vintage Guitar Magazine, profiles more than 100 historic and unique electric bass models from such makers as Alembic, Danelectro, Fender, Gibson, Gretsch, Guild, Hamer, Kramer, Rickenbacker, and many others. Rare and legendary instruments, from the earliest attempts at amplified basses in the mid-1930s to the cutting-edge instruments of today, are presented in more than 250 color and period photos. The main feature of this book is the exclusive coverage of historic and one-of-a-kind basses owned and played by such famed musicians as: Bill Black (Elvis Presley), Tim Bogert (Vanilla Fudge), Mark Egan (Pat Metheny Group), John Entwistle (The Who), Paul Goddard (Atlanta Rhythm Section), Bruce Hall (REO Speedwagon), Greg Lake (Emerson, Lake & Palmer), Benjamin Orr (The Cars), Tom Petersson (Cheap Trick), Carl Radle (Derek and the Dominos), Gene Simmons (Kiss), Steve Wariner, and others.

First published in 1998, this volume argues that two conditions need to be met for any agreement between people with conflicting desires to count as an unforced one, namely, that the parties argue as if they had equal power and that their antipathy to being coerced exceeds their desire to coerce others. These conditions entail objective moral principles and a theory of justice, modifying and developing Rawls' contractarian theory, but without the veil of ignorance. They support Rawls on basic civil liberties and constitutional liberal democratic government, including religious tolerance, anti-paternalism, anti-racism and anti-sexism, but dispute his Difference Principle, his circumstances of justice, Laws of Peoples, reflective equilibrium, and freedom of conscience as a basic liberty. The book also gives a contractarian account of epistemology, metaethics, education, the rationality of being moral, the rights of animals and other non-persons, and the rights of indigenous peoples. Writers such as Brian Barry, R.S. Peters, Isaiah Berlin, Vinit Haksar, Jurgen Habermas, R.M. Hare, Philip Pettit, Derek Parfit, Michael Smith, Peter Geach, Philippa Foot, Bronwyn Davies, Quentin Skinner and Will Kymlicka are also discussed.

This volume gathers the contributions of senior and junior scholars - all indebted to the pathbreaking work of Derek Pearsall - to showcase new research prompted by his rich and ongoing legacy as a literary critic, editor, and seminal founder of Middle English manuscript studies. The contributors aim both to honor Pearsall's work in the field he established and to introduce the complexities of interdisciplinary manuscript studies to students already familiar with medieval literature.The contributors explore a range of issues, from the study of medieval literary manuscripts to the history of medieval books, libraries, literacy, censorship, and the social classes who used the books and manuscripts - nobles, children, schoolmasters, priests, merchants, and more. In addressing reading practices, essays provide a wealth of information on marginal commentaries, images and interpretive methods, international transmission, and early print and editorial methods.Contributors: Sarah Baechle, Julia Boffey, Peter Brown, Katie Ann-Marie Bugyis, Christopher Cannon, A. I. Doyle, Martha W. Driver, Sian Echard, Nicole Eddy, A. S. G. Edwards, Hilary E. Fox, Karrie Fuller, Maura Giles-Watson, Phillipa Hardman, Kathryn Kerby-Fulton, Jill Mann, William Marx, Sarah McNamer, Carol M. Meale, Linne Mooney, Melinda Nielsen, Theresa O'Byrne, Stephen Partridge, Oliver Pickering, Susan Powell, Elizabeth Scala, A. C. Spearing, John J. Thompson, Edward Wheatley, Jocelyn Wogan-Browne, Hannah Zdansky, Nicolette Zeeman.

Inspiring and irreverent by turns, Brian Levison's new anthology has drawn on rugby's wealth of excellent writing. Frank Keating, P. G. Wodehouse, Alec Waugh, A. A. Thomson, John Reason and Mick Imlah are among the distinguished names who have written movingly, amusingly and entertainingly about the game they loved. Great players such as Brian O'Driscoll, Willie John McBride, J. P. R. Williams, Chester Williams, Colin Meads, Gavin Hastings and Brian Moore give us a fascinating insider's view, as does World Cup Final referee Derek Bevan, who reveals what it is like to try to control thirty powerful and often volatile men in a highly competitive situation. But some of the best writing and the wittiest insights come from those who played their rugby at a much less exalted level. The origins of the game - sometimes true, sometimes fanciful - are explored as are some of its rituals like the haka. There are amusing tales including that of the four Tibetan boys sent by the Dalai Lama to learn the game at Rugby School and an account of New Zealand scrum-half Chris Laidlaw's hostile reception at a village fete in Wales. Along with barely believable stories about the game's hardest men, including the French coach Jean 'le Sultan' Sebedio, who used to conduct training sessions wearing a sombrero and wielding a long whip, and 'Red' Conway who had his finger amputated rather than miss a game for South Africa. One section 'Double Vision' looks at the same incident from opposing viewpoints, such as when the then relatively inexperienced Irish immortal Willie John McBride took a swing at the mighty All Black Colin Meads in a line-out. Another, 'Giving it Everything', shows how exceptional courage was not restricted to the rugby field but extended to the battle grounds of the First World War. From the compiler of highly acclaimed All in a Day's Cricket, this selection covers the game from virtually every angle and is sure to delight any rugby fan.

In a relatively short period of time, cognitive behaviour therapy has become the leading psychotherapy in most Western countries. Much of the appeal and success of cognitive behaviour therapy is due to the close links between science and practice which characterise the cognitive behaviour therapy movement and to the demonstrated effectiveness of the treatment approach. This book, which is divided into two parts, illustrates the links between science and practice in modern Cognitive Behaviour Therapy. Part One covers general issues and includes chapters on: The Evolution of Cognitive Behaviour Therapy (Stanley Rachman); The Foundations of Cognitive Behaviour Therapy (Michael Gelder); Information Processing Biases in Emotional Disorders (Andrew Mathews); The Relationship Between Cognition and Emotion (John D Teasdale); Efficacy and Dissemination of Psychological Treatment (David H. Barlow and Stefan G Hofmann).Part Two focuses on specific disorders and includes chapters on: Panic Disorder and Social Phobia (David M Clark); Generalized Anxiety Disorder (Adrian Wells and Gillian Butler); Obsessive-Compulsive Disorder (Paul M Salkovskis and Joan Kirk); Eating Disorders (Christopher G Fairburn); Sexual Problems (John Bancroft); Depression (J Mark G Williams); Attempted Suicide (Keith Hawton) Hypochondriasis (Paul M Salkovskis and Christopher Bass); Cardiovascular Disease (Derek W Johnston) Atypical Chest Pain (Richard Mayou); Chronic Fatigue (Michael Sharpe); Problem-Solving Treatment in Primary Care (Denis Gath and Laurence Mynors-Wallis). Each of the chapters in Part Two outlines the current cognitive behavioural conceptualization of the disorder, reviews relevant research and describes current cognitive behavioural treatment procedures. The book will be of interest to clinicians and researchers from a wide range of backgrounds, as well as students and trainees in clinical psychology, psychiatry and psychotherapy.

The production, transmission, and reception of texts from England and beyond during the late medieval and early renaissance periods are the focus of this volume. Chapters consider the archives and the material contexts in which texts were produced, read, and re-read; the history of specific manuscripts and early printed books; and some of the continuities and changes in literary and book production, dissemination, and reception in the fifteenth and sixteenth centuries. Responding to Professor Julia Boffey's pioneering work on medieval and early Tudor material and literary culture, they cover a range of genres - from practical texts written in Latin to works of Middle English poetry and prose, both secular and religious - and examine an assortment of different reading contexts: lay, devotional, local, regional, and national. TAMARA ATKIN is Senior Lecturer in Late Medieval and Early Renaissance Literature, and JACLYN RAJSIC is Lecturer in Medieval Literature, at the School of English and Drama, Queen Mary University of London. Contributors: Laura Ashe, Priscilla Bawcutt, Martin Camargo, Margaret Connolly, Robert R. Edwards, A.S.G. Edwards, Susanna Fein, Joel Grossman, Alfred Hiatt, Pamela M. King, Matthew Payne, Derek Pearsall, Corinne Saunders, Barry Windeatt, R.F. Yeager.

This acclaimed study of English medieval manuscripts and early printed books - many items from Professor Takamiya's own collection - quickly sold out in hardcover. The subjects range from Saint Jerome to Tolkien, with particular concentrations on Chaucer, Gower, Malory and religious and historical writings of the late middle ages. There are essays examining the work of early printers such as Caxton and de Worde, and of bibliophiles and antiquarians in modern times. Befitting a tribute to a bibliophile, this volume has been handsomely designed by Lida Kindersley of the Cardozo Kindersley Workshop in Cambridge, and is extensively illustrated. The volume as a whole constitutes a substantial body of research on medieval English literature, and early books and manuscripts. Contributors: Richard Barber, Nicolas Barker, Richard Beadle, N.F. Blake, Julia Boffey, Piero Boitani, Derek Brewer, Helen Cooper, A.I. Doyle, Martha W. Driver, A.S.G. Edwards, P.J.C. Field, Christopher de Hamel, Ralph Hanna, Lotte Hellinga, Kristian Jensen, Edward Donald Kennedy, Richard A. Linenthal, Jill Mann, Takami Matsuda, David McKitterick, Rosamond McKitterick, Linne R. Mooney, Ruth Morse, Daniel W. Mosser, Tsuyoshi Mukai, Paul Needham, M.B. Parkes, Derek Pearsall, Oliver Pickering, P.R. Robinson, Michael G. Sargent, John Scahill, Kathleen L. Scott, Jeremy J. Smith, Isamu Takahashi, John J. Thompson, Linda Ehrsam Voigts, Yoko Wada, Bonnie Wheeler, Patrick Zutshi.

A moving and thoughtful tribute, this book, originally published in 1979, offers fourteen essays dedicated to the memory of J. R. R. Tolkien (1892-1973). The contributors, a distinguished group of his friends, colleagues, and former students, address a wide and diverse range of subjects. The first part of the book contains material on Tolkien the man and the scholar. It includes his obituary notices from The Times of London and his valedictory address at Oxford in which he points out, eloquently and purposefully, the artificiality of the split between language and literary study. The second part consists of critical essays representing Tolkien's major scholarly interests-Old Norse, Old English, and Middle English literatures. The last part includes three pieces on Tolkien's popular writings, particularly The Lord of the Rings, and a bibliography of his published writings. Contributors: J. A. W. Bennett, A. J. Bliss, Derek S. Brewer, Humphrey Carpenter, S. T. R. O. d'Ardenne, William Dowie, Ursula Dronke, Robert T. Farrell, P. J. Frankis, Douglas Gray, Fred C. Robinson, Geoffrey T. Shepherd, T. A. Shippey, E. G. Stanley, J. R. R. Tolkien, Rosemary Woolf

The publication of proceedings of conferences has often been so delayed that they are useless both to active workers in the field and for cur- rently appropriate teaching. Rapid publication on the other hand may impose very difficult conditions upon authors and demand unwelcome sacrifices. We wish to thank the many speakers at ESCAT for their co- operation in providing manuscripts and to apologise to those unable for reasons beyond their control to fall in with the rigorous editorial policy. To get this book out at the earliest possible moment we have also cut the normal consultation between editors and authors to a minimum. One decision made in the interests of uniformity was to re- place the various terms used by different writers by one, C. A. T. , consistent with the title of the Seminar of which the book is arecord. The organisers of ESCAT decided upon a largely didactic meeting with as little overlap as was practicable between contributions and a de- termined attempt to view computerised axial tomography in the light of its clinical usefulness.As consequence, the purpose of this book is to provide a comprehensive introduction to the whole field for clin- icians as weIl as radiologists. The editors wish to acknowledge the very efficient help and encourage- ment of the publishers and the hard secretarial work of Miss G. JOHNS, as weIl as the editorial assistance of Dr. DEREK KINGSLEY. London, Spring 1977 G. H. DU BOULAY . I. F.

Created in London c. 1340, the Auchinleck manuscript (Edinburgh, National Library of Scotland Advocates MS 19.2.1) is of crucial importance as the first book designed to convey in the English language an ambitious range of secular romance and chronicle. Evidently made in London by professional scribes for a secular patron, this tantalizing volume embodies a massive amount of material evidence as to London commercial book production and the demand for vernacular texts in the early fourteenth century. But its origins are mysterious: who were its makers? its users? how was it made? what end did it serve? The essays in this collection define the parameters of present-day Auchinleck studies. They scrutinize the manuscript's rich and varied contents; reopen theories and controversies regarding the book's making; trace the operations and interworkings of the scribes, compiler, and illuminators; tease out matters of patron and audience; interpret the contested signs of linguistic and national identity; and assess Auchinleck's implied literary values beside those of Chaucer. Geography, politics, international relations and multilingualism become pressing subjects, too, alongside critical analyses of literary substance. Susanna Fein is Professor of English at Kent State University and editor of The Chaucer Review. Contributors: Venetia Bridges, Patrick Butler, Siobhain Bly Calkin, A. S. G. Edwards, Ralph Hanna, Ann Higgins, Cathy Hume, Marisa Libbon, Derek Pearsall, Helen Phillips, Emily Runde, Timothy A. Shonk, Miceal F. Vaughan.

Hvorfor skal vi lese mediehistorie? Å forstå den tiden vi lever i, innebærer å forstå hvordan fortidens mennesker kommuniserte. Dagens medier, teknologi og symboler har konkurrert med og bygger på tidligere uttrykk - i stil, form og konkurranse. «Norsk mediehistorie» begynner med vikingtidens steinhogging før den kort tar oss gjennom boktrykkerkunsten og eneveldes sensur, inntil mediesamfunnet slår ut i full, politisk blomst i 1814. På Eidsvoll fikk vi valgfrihet for noen, trykkefrihet for nesten alle, og en fullverdig opposisjonell journalistikk. Norge ble et mediesamfunn med vekst i aviser og stadig nye lokale kanaler. Fotografiet kom, deretter grammofonen, så filmen, radioen og fjernsynet, og til sist internett med alle sine muligheter. Vi fikk romaner, tegneserier og show i radio og tv, blogger, byråer og delinger slik vi kjenner dem i dag. Vi fikk kort sagt hele den vidunderlige nye verden der alle snakker med alle, der de ansvarlige kommer med sine argumenter like fullt som nettrollene med sitt raseri. Henrik Bastiansen og Hans Fredrik Dahl tar oss med gjennom denne merkelige historien om landets vei fra fattig provins til yrende rikt mediesamfunn. 3. utgave av «Norsk mediehistorie» er revidert og ajourført, og rommer et nytt, fyldig kapittel om internett og digitale medier. Resultatet er en bok til glede for alle som vil forstå fortidens og nåtidens medier med deres aktører og stjerner - fra Marcus Thrane til skuespillerne i Skam. Dette er en bok for studenter, personer og familier landet rundt som med sitt vitebegjær og sin lattertrang har bestemt mye av utviklingen i medienes mentalitet.

Det globale samfunnet stiller nye krav til samarbeid. Det er ikke lenger sikkert at samarbeidspartneren din kommer fra samme sted som deg selv, geografisk, faglig eller kulturelt. Det er ikke lenger sikkert at dere deler en felles plattform for samarbeid. Kanskje det eneste dere har felles, er at dere begge er mennesker. Da er vi nede på «grunnfjellet» for mellommenneskelige relasjoner. Hva består dette grunnfjellet av? Eller med andre ord: Hva vil det si å være et menneske blant andre mennesker? Forfatterne har hentet inspirasjon fra de tre tenkerne Martin Buber, Emmanuel Levinas og Knud E. Løgstrup og deres forståelse av møtet med den andre. Dette har ledet dem til en mer inngående beskrivelse av egenskaper ved «det gode samarbeid», nemlig ansvar, respekt, åpenhet og tillit.